Khaleesi is a Dothraki title referring to the wife of the khal. She could either be very influential; riding next to the khal, or she could be worth practically less than the khal's horse - the khal's bloodriders would sometimes share the khaleesi, but never share the khal's horse at some Dothraki places.

In the Dothraki traditions, if a khal dies, his khaleesi must retire to join the crones that rule Vaes Dothrak, known as the dosh khaleen. Daenerys Targaryen, however refused this and declared herself a khaleesi in her own right and formed her own Khalasar from the few of Drogo's people who hadn't abandoned her.